Researchers think Vitamin B6 supplementation might also be useful for alleviating depression, anxiety, and agitation because it increases the production of serotonin and GABA which elevates mood. Vitamin B6 is a cofactor for enzymes involved in one of the two pathways for the metabolism of homocysteine, a byproduct that might cause vascular damage, impaired endothelium dependent vasodilation due to reduced nitric oxide activity, and increased clotting in blood vessels. For kidney stones, Vitamin B6 is thought to be beneficial by decreasing urinary excretion of oxalate in some patients. Most kidney stones are composed of calcium oxalate, and high urinary oxalate has been associated with development and recurrence of kidney stones.